Objective To evaluate the clinical efficacy of ultrasonography combined with puncture biopsy for the diagnosis of anterior lymph nodes in breast cancer using Meta-analysis. Methods Systematic development of literature search methods and principles of literature screening

Chinese search subject terms for ultrasonography

breast puncture

puncture biopsy

puncture cytology examination

breast cancer

anterior lymph node metastasis in Chinese databases China Knowledge Network (CNKI)

Wanfang

China Biomedical Literature Database (CBM)

Vipers (VIP)

Longyuan Journal

Medical Library

National Research Database; English search Subject terms were Contrast Ultrasound

Breast cancer

Needle biopsy

Sentinel lymph node metastasis

Sentinel Lymph node biopsy in foreign language databases PubMed

Embase

NEJM medical journal

Cochrane Library; literature related to puncture biopsy combined with ultrasonography for the diagnosis of anterior lymph node metastasis of breast cancer published before June 31

2021 was selected and Meta-analysis was completed. Results A total of 6 Chinese literature and 6 English literature were retrieved and included according to the screening criteria

with a total of 1645 study subjects

which showed no significant pattern of SLN in breast cancer patients; the combined statistics were combined SEN=0.685 (95% CI: 0.55-0.80)

combined SPE=1.000 (95% CI: 0.99-1.00)

combined SCC= 0.903 (95% CI: 0.68 to 0.95)

combined diagnostic ratio = 258.29 (95% CI: 97.82 to 721.58)

combined positive predictive value = 1.000 (95% CI: 0.98 to 1.00)

combined negative predictive value = 0.93 (95% CI: 0.87 to 0.98). Conclusion Patients with positive breast cancer by ultrasonography-guided mammocentesis can be treated directly with axillary lymph node dissection

while negative patients still need to be considered in combination with SLNB diagnosis to develop a treatment plan.