Objective To investigate the effect of plasma homocysteine(Hcy) on the changes of left ventricular geometry in patients with obstructive sleep apnea syndrome (OSAS). Methods A total of 192 patients with OSAS diagnosed with apnea index (AHI)≥5times/h by polysomnography (PSG) were selected. Blood pressure

blood glucose

blood lipids

and plasma homocysteine levels were measured the next morning. For echocardiography

30 healthy people whose gender

age match

blood glucose

blood lipids

chest radiograph

electrocardiogram and PSG were normal were selected as the control group. According to the left ventricular mass index (LVMI) and relative wall thickness (RWT)

OSAS patients are divided into four groups according to the geometric configuration of the left ventricle: normal configuration group (NG)

concentric remodeling group (CR)

and concentric hypertrophy Group (CH)

eccentric hypertrophy group (EH). The difference of plasma Hcy levels between the control group and the OSAS four groups was compared

and the single-factor correlation analysis between plasma Hcy and other parameters was performed

and the multivariate stepwise regression analysis was further performed. Results ① Compared with the control group

the plasma Hcy levels of the CR

CH

and EH groups increased

and the difference was statistically significant (P<0.05); compared with the NG and CR groups

the plasma Hcy levels of the CH and EH groups increased High

the difference was statistically significant (P<0.05); Compared with the EH group

the plasma Hcy level in the CH group increased

and the difference was not statistically significant (P>0.05); ② Univariate correlation analysis of plasma Hcy and BMI

SBP

Abdominal circumference

AHI

blood glucose

LVMI

abnormal left ventricular geometric configuration are positively correlated

and are negatively correlated with Em/Am

LVEF

and are correlated with gender

age

DBP

neck circumference

hip circumference

T90

MSaO2

LSaO2

RWT No correlation; ③Further analysis of multivariate stepwise linear regression showed that plasma Hcy was independently related to AHI

LVMI

and abnormal left ventricular geometry. Conclusion The expression levels of plasma Hcy in patients with different left ventricular geometric configurations of OSAS are different. The level of plasma Hcy is one of the main influencing factors of changes in left ventricular geometric configuration (CH

EH) in patients with OSAS.