Objective: To investigate the clinical value of peak strain dispersion（PSD） in evaluating leftventricular systolic synchrony in patients with chronic kidney disease（CKD）. Methods: 96 patients with CKD were divided into two groups according to the glomerular filtration rate（GFR） level.There were 50 cases in GFR 30-89ml/min group（group A），and 46 cases in GFR＜30 ml / min group（group B），and 50 healthy people were selected as the control group.All the three groups were examined by transthoracic two-dimensional echocardiography，measuring the parameters of conventional echocardiography，collecting the two-dimensional dynamic images of apical four chamber and three chamber views，and two chamberlong axis view of Left ventricular for three consecutive cardiac cycles.The left ventricular PSD and left ventricular global longitudinal strain（LVGLS） were calculated，parameters of cardiac configuration and functional among the three groups were compared，and the correlation between PSD and LVGLS was analyzed. Results: Except for left ventricular ejection fraction (LVEF) and left ventricular diameter shortening rate (LVFS)

the conventional parameter values were significantly higher in group B than in the control group and group A (all P＜0.05）. There were no significant differences in conventional echocardiographic parameters between group A and the control group. PSD gradually increased from control group to group A and then to group B，and the difference among the groups was statistically significant（all P＜0.05）.LVGLS gradually decreased from control group to group A and then to group B，and the difference among the groups was statistically significant（all P＜0.05）；PSD was negatively correlated with LVGLS. Conclusion: PSD could early and quantitatively detect left ventricular systolicsynchrony in CKD patients，the systolic synchrony in CKD patients decreases gradually with the development of disease，PSD can be used as a new reliable index to evaluate left ventricular systolic synchrony.