: Objective: Explore musculoskeletal ultrasound to evaluate the effects of primary Sjogren’s syndrome (PSS) arthritis and the immune biochemical characteristics of patients. Methods: All 81 patients with PSS were admitted between April 2019 and April 2020. Musculoskeletal ultrasound and immuno-biochemical tests were performed to analyze the accuracy

specificity

and sensitivity of musculoskeletal ultrasound. According to the diagnosis results

PSS patients were classified Divided into arthritis group (n=65) and non-arthritis group (n=16). The ultrasound examination results

immunobiochemical indexes

and age of the two groups were compared. Results: Among the 81 patients with PSS

65 were diagnosed with arthritis at a later stage

and the prevalence was 80.25% (65/81). The accuracy of musculoskeletal ultrasound examination was 96.30%

the sensitivity was 96.92%

the specificity was 93.75

and the AUC was 0.953

which has high predictive accuracy. In the arthritis group

bone erosion

osteophytes

tendon tenosynovitis

joint space stenosis

synovitis

joint effusion rate and blood flow signal score were higher than those of non-arthritis patients (P<0.05)

and the thickness of synovial membrane was thicker than that of non-arthritis Those with inflammation (P<0.05). From the perspective of immunobiochemical indicators

there is no statistical difference between the two groups in IgA and IgM indicators (P>0.05)

while the age

RF

IgG

ESR

and CRP of the arthritis group are higher than those of the non-arthritis group (P<0.05); The prevalence of PSS arthritis is negatively correlated with age

RF

IgG

ESR

CRP

synovial thickness

blood flow signal

SSDAI score

and is associated with bone erosion

osteophytes

tendon tenosynovitis

joint space stenosis

synovitis

There is a positive correlation with joint effusion. Conclusion: Musculoskeletal ultrasound has high specificity and sensitivity in the assessment of PSS joints. In conjunction with immuno-biochemical testing

it is found that patients with PSS arthritis have hyperimmune inflammation and hyperglobulinemia

which are manifested as RF

IgG

ESR

CRP index increased.