?Abstract Purpose To explore the clinical significance of contrast enhancement characteristics of contrast-enhanced ultrasound in the diagnosis of focal peripheral lung lesions. Methods 116 peripheral pulmonary lesions were retrospectively analyzed

including 62 benign lesions and 54 malignant lesions. Lesions ultrasonic imaging enhancement phase (Δ T < 2.5s for early enhancement

Δ T≥ 2.5s for late enhancement ) and the enhancement patterns were recorded

and the difference between benign and malignant lesion group was compared

and then the diagnosis efficiency was analyzed. Results In the benign lesion group

early enhancement was dominant

while in the malignant lesion group

late enhancement was dominant

accounting for 82.3% and 64.8%

respectively

there was a statistically significant difference between benign and malignant lesions in the enhancement phase (P<0.05). In enhancement mode

the benign lesion group was characterized by Rapid basement dendrite enhancement

while the malignant lesion group was characterized by Dot chip enhancement

the difference between benign and malignant lesions was statistically significant (P<0.05). Early enhancement and Rapid basement dendrite enhancement were used as indicators to judge benign lesions

with sensitivity

specificity and accuracy (82.3%

22.6%)

(66.7%

94.4%) and (75.0%

56.0%)

respectively. Late enhancement and Dot chip enhancement were used as the indicators of malignant lesions

respectively

and their sensitivity

specificity and accuracy were (64.8%

68.5%)

(85.5%

62.9%)

(75.9%

65.5%)

respectively. Conclusion contrast-enhanced ultrasound is of high clinical value in the differential diagnosis of focal benign and malignant lesions of peripheral lung.