甲状腺乳头状癌超声特点、BRAF V600E基因突变与颈部淋巴结转移相关性分析

周芳; 张刚; 李欢; 张哲; 罗东林

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甲状腺乳头状癌超声特点、BRAF V600E基因突变与颈部淋巴结转移相关性分析

经验交流 | 更新时间：2023-10-11

- 甲状腺乳头状癌超声特点、BRAF V600E基因突变与颈部淋巴结转移相关性分析
- Correlation analysis of ultrasound characteristics, BRAFV600E gene mutation and cervical lymph node metastasis in papillary thyroid carcinoma
- 临床超声医学杂志 2023年25卷第4期
- 作者机构：
  
  陆军军医大学大坪医院
- 作者简介：
- 基金信息：
  
  甲状腺结节风险分层及甲状腺癌早期诊断关键技术(cstc2017shmsA130006)
- DOI：
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-4-28，
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周芳, 张刚, 李欢, 等. 甲状腺乳头状癌超声特点、BRAF V600E基因突变与颈部淋巴结转移相关性分析[J]. 临床超声医学杂志, 2023,25(4).

Correlation analysis of ultrasound characteristics, BRAFV600E gene mutation and cervical lymph node metastasis in papillary thyroid carcinoma[J]. Journal of Clinical Ultrasound in Medicine, 2023,25(4).
周芳, 张刚, 李欢, 等. 甲状腺乳头状癌超声特点、BRAF V600E基因突变与颈部淋巴结转移相关性分析[J]. 临床超声医学杂志, 2023,25(4). DOI：

Correlation analysis of ultrasound characteristics, BRAFV600E gene mutation and cervical lymph node metastasis in papillary thyroid carcinoma[J]. Journal of Clinical Ultrasound in Medicine, 2023,25(4). DOI：

摘要

目的分析甲状腺乳头状癌（PTC）二维超声图像特征及BRAF V600E突变与颈部淋巴结转移的关系。方法选取于我院行甲状腺癌根治术患者316例，根据甲状腺癌术后病理分期（pTNM），将无颈部淋巴结转移（pN0）者归为（未转移组），有颈部淋巴结转移（pN1）者归为转移组，比较两组二维超声图像特征、临床资料、BRAF V600E突变的差异。采用多因素Logistic回归分析PTC超声图像特征、BRAF V600E突变与颈部淋巴结转移的关系。结果 316例PTC患者中，转移组156例（49.4%），98例（62.8%）发生BRAF V600E突变；未转移组160例（50.6%），121例（75.6%）发生BRAF V600E突变。转移组与未转移组在年龄、病灶数目、大小、沙粒钙化、纵横比、肿瘤边缘、病灶与被膜关系、累及腺叶比较，差异均有统计学意义（均P＜0.05）。多因素Logistic回归分析显示，患者年龄、肿瘤大小、沙粒钙化、纵横比、病灶与被膜关系、累及腺叶是发生颈部淋巴结转移的危险因素（均P＜0.05）。结论 PTC颈部淋巴结转移与患者年龄、肿瘤大小、沙粒钙化、纵横比、病灶与被膜、累及腺叶关系有关，与性别、病灶数目、肿瘤边缘、BRAF V600E突变无关。

Abstract

ABSTRACT Objective To analyze the characteristics of two-dimensional ultrasound images of papillary thyroid carcinoma (PTC) and the relationship between BRAFV600E mutation and cervical lymph node metastasis. Methods 316 patients with thyroid cancer underwent radical surgery in our hospital were selected. According to the pathological stage (pTNM) of thyroid cancer after surgery

those without cervical lymph node metastasis (pN0) were classified as (non metastasis group)

and those with cervical lymph node metastasis (pN1) were classified as (metastasis group). The differences of two-dimensional ultrasound image characteristics

clinical data and BRAFV600E mutation between the two groups were compared. Multi-factor logistic regression analysis was used to analyze the characteristics of PTC ultrasound image and the relationship between BRAFV600E mutation and cervical lymph node metastasis. ResuLts Among 316 PTC patients

156 (49.4%) in the metastatic group

98 (62.8%) had BRAFV600E mutation; 160 (50.6%) in the non-metastatic group

121 (75.6%) had BRAFV600E mutation. There were statistically significant differences between the metastatic group and the non-metastatic group in terms of age

number and size of lesions

sand calcification

aspect ratio

tumor margin

the relationship between lesions and membrane

and involvement of glandular lobes (all P<0.05). Multivariate logistic regression analysis showed that patients' age

tumor size

sand calcification

aspect ratio

the relationship between lesion and membrane

and the involvement of glandular lobe were risk factors for pN1（all P< 0.05）. Conclusion The cervical lymph node metastasis of PTC is related to the patient's age

tumor size

sand calcification

aspect ratio

the relationship between the lesion and membrane

and the glandular lobe involved

but not to gender

number of lesions

tumor margin

and BRAF V600E mutation.

关键词

超声检查甲状腺乳头状癌声像图特征颈部淋巴结转移基因突变

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