Deng Ling. Clinical features of 201 patients with dengue fever in Chongqing Liangjiang New Area[J]. Journal of Chongqing Medical University, 2022,47(9):1111-1115.
Deng Ling. Clinical features of 201 patients with dengue fever in Chongqing Liangjiang New Area[J]. Journal of Chongqing Medical University, 2022,47(9):1111-1115.DOI:
目的: 提高临床医师对登革热的认识水平。方法: 回顾性分析2019年8至10月两江新区第一人民医院确诊收治的201例登革热患者临床资料。计数资料采用卡方检验,计量资料采用t检验。结果: 201例登革热患者中,男性97例(48.26%),女性104例(51.74%),>60岁患者(老年组)40例(19.90%)。主要临床表现为发热(99.00%)、乏力(85.07%)、肌肉酸痛(85.57%)。实验室检查显示,多数患者有中性粒细胞减少(90.53%)、血小板减少(70.00%)、肝功能损害(30.00%)。老年组血小板下降发生率较青中年组高(66.67% vs. 85.25%,P=0.04)。此外,老年组肝功能损害发生率较高(50.00% vs. 25.64%,P=0.01),且肝功能损害更重。病原学检查显示,本地感染患者均为基因1型,2例输入性病例分别为基因2型和基因3型。治疗主要以对症支持治疗,多数为轻症,预后好。结论: 本次登革热流行主要为基因1型,以发热、乏力、肌肉酸痛为典型临床表现,多伴有中性粒细胞及血小板下降、肝功能损害,老年患者更为明显,需引起高度重视。
Abstract
Objective: To improve clinician’s understanding of dengue fever. Methods: The clinical data of 201 dengue fever patients admitted to the First People’s Hospital of Liangjiang New Area from August to October
2019 were retrospectively analyzed. Chi-square was used for discontinuous variables
and t test was used for continuous variables. Results: Among 201 dengue fever patients
97 (48.26%) were male
and 104 (51.74%) were female. The number of them over 60 years old was 40 (19.90%). The common manifestations included fever (99.00%)
feeble (85.07%)
and myalgia soreness (85.57%). Laboratory examination showed that most patients had neutropenia (90.53%)
thrombocytopenia (70.00%)
and liver function damage (30.00%). The incidence of thrombocytopenia was higher in elderly patients than that in young and middle-aged patients (66.67% vs. 85.25%
P=0.04). In addition
the incidence of liver damage in the elderly patients was higher (50.00% vs. 25.64%
P=0.01)
with more serious damage. Etiological examination showed that all patients’ dengue virus RNA (DENA-RNA) were positive
the locally infected patients were genotype 1
and two imported patients were genotype 2 and genotype 3. All patients were treated by symptomatic support to prevent complications
most patients with mild symptoms and with good prognosis. Conclusion: In 2019
the epidemic of dengue fever in our district is mainly genotype 1