Even though the infection of hepatitis B virus (HBV) has been reduced by the vaccination and the improvement of human health awareness

and the gradual development of antiviral drugs. So far

the elimination of HBV is still a serious problem. Hence

the accurate detection rate of HBV is extremely important. The traditional serum makers HBV DNA and hepatitis B surface antigen (HBsAg) have certain limitations in assessing the anti-HBV efficacy and accurately reflecting the transcriptional activity of covalently closed circular DNA (cccDNA). In order to solve this situation

novel HBV serum markers have been developed

such as HBV surface antigen

HBV RNA

HBV core related antigen

and HBV large surface protein. Based on the different reference values of different markers in disease diagnosis

this article briefly summarizes the clinical applications and limitations of these markers

which aims to provide references for the efficient and accurate detection of HBV and clinical prognosis.