Objective: To compare the variation in and internal diameters of the surrounding arteries in patients with gastric cancer and non-gastric cancer and analysis it’s impact on surgery. Methods: A retrospective analysis of 86 cases of gastric cancer and 92 cases of non-gastric cancer from January 2018 to January 2020. All patients underwent digital subtraction angiography. The variations and the inner diameters in the gastric surrounding arteries were measured by imaging. The anatomical differences between gastric cancer and non-gastric cancer patients were analyzed. The impacts on surgical difficulty and major surgical complications were also analyzed. Results: There were 165 (92.7%) patients in type I

11 (6.2%) patients in type II

and 2 (1.1%) patients in type IV according to a simple classification of the left gastric artery. There were 148 (83.1%) right gastric arteries (RGAs) originating from the proper hepatic artery (PHA)

3 (1.7%) originating from the gastroduodenal artery (GDA)

and 16 (9.0%) originating from the left hepatic artery or right hepatic artery. The RGA was absent in 11 (6.2%) patients. The average inner diameters of the LGA

RGA

right gastroepiploic artery (RGEA)

and GDA were 2.50 mm

1.42 mm

1.73 mm

and 2.89 mm

respectively. The average inner diameter of the RGEA was 1.87 mm in gastric cancer patients

which was wider than the 1.60 mm in non-gastric cancer patients (P=0.001). The operation time[ (254.0±54.0) min] and surgical blood loss [ (113.5±43.0) mL] in the patients with the type Ⅰc left gastric artery were significantly prolonged

and we found that the artery variations had no impact on the major complications of the operation. Conclusion: No difference was found in anatomical variation in patients with gastric cancer and non-gastric cancer. Patients with gastric cancer had a wider inner diameter of the RGEA. The type Ⅰc left gastric artery increased the difficulty of surgery.