Abstract: ObjectiveTo study the effect of amelogenin (AML) on the migration

adhesion and proliferation of periodontal ligament stem cells (PDLSCs).MethodsSTRO-1+PDLSCs were selected by Flow cytometer.The transwell system was used to detect the effect of AML on migration of PDLSCs. Cells attachment assay was used to detect the effect of AML on adhesion of PDLSCs.MTT was used to detect the effect of AML on the proliferation of PDLSCs.ResultsThe results of transwell showed that AML could induce the migration of PDLSCs with positive correlation.Cells attachment assay showed that the adhesion of PDLSCs was effected by AML as well

and the effect was increased with the extension of incubation time.Results of MTT showed that AML could promote the proliferation of PDLSCs in a dose dependent manner.ConclusionAML could increase the proliferation

adhesion and migration potential of PDLSCs.K