Abstract: ObjectiveTo investigate the best injection position and curative effect of ultrasound-guided thrombin injection (UGTI) on femoral pseudoaneurysm (FPA).MethodsReview the data of FPA cases in the neurology department of southwest hospital from January 2010 to June 2015.Detailed clinical information of the patients，including the curative effect of local compression therapy

the position

method

dosage and curative effect of ultrasound-guided thrombin injection were collected and analyzed.ResultsFrom January 2010 to June 2015，43 cases (1.20%) of FPA were diagnosed in 3573 patients undergoing cerebrovascular interventional operation.Local compression therapy was effective in 11 of 43 FPA patients.The remaining 32 patients who had no response to local compression therapy were treated by UGTI

and the average dosage of thrombin was (30±12) IU. All FPA were blocked successfully within 1 minute and without any distal embolism events after the first UGTI attempt.No relapse and complications occurred during the follow-up of 5 to 70 months

averagely (38.69±20.79) months.ConclusionUGTI is effective for treatment of FPA who had no response to local compression therapy.Thrombin injection at position far away from the blood flow direction of pseudoaneurysm neck crevasse with ultrasound-guided could bring about highe success rate，less amount of thrombin，and less complications.