Abstract： ObjectiveTo research the efficacy of different dose botulinum toxin A in the treatment of patients with neurogenic detrusor overactivity due to spinal cord injury or multiple sclerosis.MethodsThe datas of 43 patients with neurogenic detrusor overactivity caused by spinal cord injury or multiple sclerosis which accepted treatment in our hostipal were analyzed.And 38 patients were followed up for 12 weeks

of which 20 cases were treated with 200 U botulinum toxin A

and 18 cases received 100 U botulinum toxin A. The average age of 38 patients was 45.3

and the ratio of famale was higher.The incontinence quality of life（I-QOL）changed from baselin after 6 weeks and 12 weeks was recorded.ReslutsThe final outcomes showed that the efficacy of botulinum toxin A with 200U was better than that with 100 U according to I-QOL score

and the difference was statistical significance(P＜0.05).ConclusionThe botulinum toxin A has positive effect on neurogenic detrusor overactivity，and the efficacy of 200 U injection is better than that of 100 U.