肝细胞肝癌伴脉管癌栓单纯手术切除与切除术后联合介入治疗预后对比

刘嘉烨; 李川; 文天夫; 严律南; 杨家印; 李波; 王文涛; 徐明清; 吴宏

您当前的位置：

首页 >

文章列表页 >

肝细胞肝癌伴脉管癌栓单纯手术切除与切除术后联合介入治疗预后对比

临床研究 | 更新时间：2023-05-22

- 肝细胞肝癌伴脉管癌栓单纯手术切除与切除术后联合介入治疗预后对比
- Prognosis of surgical excision combined with interventional therapy in treatment of hepatocellular carcinoma with microvascular invasion
- 局解手术学杂志 2016年第5期
- 作者机构：
  
  四川大学华西医院肝脏外科,四川,成都,610041
- 作者简介：
- 基金信息：
  
  国家自然科学基金（2012ZX10002-016, 2012ZX10002-017）;四川省科技厅支撑计划慢性病毒性肝炎及重症肝病综合防治研究（2015SZ0049）
- DOI：
  中图分类号：
- 纸质出版日期：2016，
扫描看全文
刘嘉烨, 李川, 文天夫, 等. 肝细胞肝癌伴脉管癌栓单纯手术切除与切除术后联合介入治疗预后对比[J]. 局解手术学杂志, 2016,(5).

LIU Jia-ye, LI Chuan, WEN Tian-fu, et al. Prognosis of surgical excision combined with interventional therapy in treatment of hepatocellular carcinoma with microvascular invasion[J]. null, 2016,(5).
刘嘉烨, 李川, 文天夫, 等. 肝细胞肝癌伴脉管癌栓单纯手术切除与切除术后联合介入治疗预后对比[J]. 局解手术学杂志, 2016,(5). DOI：

LIU Jia-ye, LI Chuan, WEN Tian-fu, et al. Prognosis of surgical excision combined with interventional therapy in treatment of hepatocellular carcinoma with microvascular invasion[J]. null, 2016,(5). DOI：

摘要

[摘要]目的分析手术切除后联合介入治疗肝细胞肝癌（HCC）伴微血管癌栓（MVI）患者的预后。方法选取我院2009年1月至2015年9月收治的296例手术切除后病理确诊为肝细胞肝癌伴微血管癌栓的连续病例作为研究对象，根据其术后是否联合应用介入治疗，分为单纯切除组（n=159）和切除术后联合介入组（n=137），分析2组患者的一般资料，对单因素分析后有显著性差异的指标进行Cox回归分析，并分别计算2组患者的长期生存率（OS）及无瘤生存率（DFS）。结果切除术后联合介入组在长期生存率及无肿瘤复发率方面均优于单纯切除组（OS:18% vs 8%

P=0.001；TRF:15% vs 8%

P=0.008）。多因素分析结果显示，慢性乙肝感染（HR 1.596

P=0.002

95%CI 1.194～2.131），肿瘤大于5 cm（HR 0.729

P=0.042

95%CI 0.539～0.989）以及多个肿瘤（HR 1.480

P=0.049

95%CI 1.002～2.186）是影响患者长期生存的不利因素。结论HCC伴MVI患者切除术后联合介入治疗可改善预后。

Abstract

Abstract: ObjectiveThe aim of this study is to analyze the long-time outcome of hepatocellular carcinoma（HCC） patients with microvascular invasion underwent liver resection combined with transarterial chemoembolization（TACE）.MethodsOur database of surgical resection from January 2009 to September 2015 was retrospectively analyzed.This study was conducted on 296 HCC patients with MVI.Patients were divided into two groups：one group underwent liver resection （n=159） and another for liver resection combined with TACE （n=137）.The 5-year overall survival rate (OS) and disease free survival (DFR) were compared.A multivariate Cox proportional hazards regression analysis was performed to assess the prognostic risk factors associated with overall survival rate.ResultsThe 5- year OS and 5- year DFR see significant difference （OS: 18%vs 8%

P=0.001；TRF:15%vs 8%

P=0.008）.Multivariate analysis revealed that HBsAg（HR 1.596

P=0.002

95% CI 1.194~2.131），tumor size>5 cm（HR 0.729

P=0.042

95% CI 0.539~0.989）as well as multiple tumors（HR 1.480

P=0.049

95% CI 1.002~2.186）were correlated to poor overall survival rate.ConclusionSurgical resection combined TACE for HCC patients with MVI realized a better prognosis than patients merely underwent therapy of resection.

关键词

肝细胞肝癌手术切除介入治疗预后总体生存率无瘤生存率

Keywords

hepatocellular carcinomaexcisoninterventional therapyprognosisoverall survivaldisease free survival

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

手术切除与介入治疗巴塞罗那C期肝癌伴门静脉癌栓患者预后比较

FEN1调节肝细胞癌发生和预后的临床意义

单纯输送鞘法经胸超声引导封堵卵圆孔未闭的临床疗效

郑氏4C悬吊法经脐单孔腹腔镜手术治疗宫颈癌的疗效及预后分析

调强放射治疗联合卡瑞利珠单抗治疗中晚期肝细胞肝癌的临床研究