Abstract: ObjectiveTo investigate the expression and early diagnosis value of CD64 index levels in peripheral blood cells in patients with postoperative traumatic sepsis.MethodsA number of 420 trauma patients were enrolled in the study

and they were divided into the postoperative traumatic sepsis group(130 cases) and postoperative general trauma group(290 cases) according to the clinical manifestations.The CD64 levels in peripheral blood were measured by flow cytometry

and the levels of C-reactive protein(CRP) and white blood cell count(WBC) were detected. The diagnostic value of these indexes on postoperative traumatic sepsis were evaluated.ResultsThe CD64 index

CRP and WBC levels in postoperative traumatic sepsis group were significantly higher than postoperative general trauma group(P<0.05). After appropriate treatment

the CD64 index

CRP and WBC levels decreased significantly compared with the preoperative levels(P<0.05).The correlation analysis showed that the CD64 index in peripheral blood and CRP level were positively correlated(r=0.79，P<0.01).However

the CD64 index in peripheral blood and WBC level were of no significant correlation(r=0.028，P>0.05).The ROC curve analysis showed that when CD64 index(7.21) considered as the boundary for early diagnosis of postoperative traumatic sepsis

the sensitivity and specificity of diagnosis for postoperative traumatic sepsis were 85.1% and 87.8%

the area under the ROC curve(AUC) was 0.865(95%CI 0.784~0.929)

which was significantly better than CRP index.ConclusionThe expression of CD64 is higher in patients with postoperative traumatic sepsis

which can be used as an effective indicator for early diagnosis of postoperative traumatic sepsis

and it has an important clinical application value.