Objective To explore the effect of minimally invasive techniques for removing impacted wisdom teeth on local inflammation and pain. Methods A total of 110 patients with impacted wisdom teeth removed in our department from June 2016 to February 2018 were divided into observation group(55 cases

minimally invasive removal) and control group (55 cases

traditional chisel) according to the surgical method. The operative status

the inflammatory mediators and pain mediators in the gingival sulcus before and after the treatment

and the therapeutic effects of the two groups were compared. Results The operative time of the observation group was shorter than that of the control group

the intraoperative blood loss was less than that in the control group

the differences were significant(P<0.05).The levels of PTX3

cells in the gingival sulcus adhesion of cytokine 1(ICAM1)

peroxidase(MPO)

prostaglandin E2(PGE2) levels

pain mediator 5hydroxytryptamine(5HT)

calcitonin generelated peptide(CGRP)

substance P(SP)

galanin(Gla) and adenosine triphosphate(ATP) in the observation group after treatment was lower than those in the control group

the differences were significant(P<0.05); The degree of mouth opening restriction

facial swelling and visual analog scale score(VAS) in the observation group were lower than those in the control group

the differences were significant(P<0.05).Conclusion Compared with traditional chisel in extraction of impacted wisdom teeth

the minimally invasive wisdom tooth extraction can relieve the inflammatory response and pain sensation of patients

and the clinical treatment effect is significant.