Objective To investigate the effect of the laparotomy and laparoscopic surgery on the stress parameters and complication of patients with gastric cancer. Methods A total of 96 patients diagnosed as gastric cancer and treated by surgery in our hospital from January 2015 to January 2017 were divided into open operation group and laparoscopy group according to the operation method

48 cases in each group. Compared the operation time

bleeding volume

dissected lymph node number

postoperative hospitalization duration and anus exhausting time and complications in 6 months after surgery.The levels of WBC

CRP

TNF-α

IL-6 in serum before and after operation were detected by enzyme-linked immuno sorbent assay and compared. Results Compared with the open operation group

the bleeding volume

postoperative hospitalization duration and anus exhausting time of laparoscopy group were better with less dissected lymph node number and longer operation time

the differences were extremely significant(P<0.01);the WBC

CRP

TNF-α

IL-6 levels of laparoscopy group at 1 day after the operation were lower than those of open operation group(P<0.05).The incidence of complication of laparoscopy group was 22.8%

which was less than 54.7% of control group

the difference was significant（P＜0.05）.Conclusion Compared with the traditional open operation

laparoscopic radical gastrectomy can shorten the hospital stays and reduce the intraoperative blood loss

the stress response and complication rate after operation.