OBJECTIVE： To optimize the dry granulation technology conditions for Yinqiao baidu tablet. METHODS： Using granulating difficulty degree and disintegration time as investigation indexes， ratio and amount of accessories microcrystalline cellulose and compressible starch in Yinqiao baidu tablet， moisture content of the sprayed powder were screened. Using yield of particle and angle of repose as indexes， L9（34） orthogonal test was used to optimize the wheel pressure， rotating speed and feeding speed in dry granulation technology， and verification test was conducted. RESULTS： The ratio of microcrystalline cellulose and compressible starch was 7 ∶ 3， and mixing ratio of the two with spray powder+inclusion compound was 1 ∶ 5. The moisture content of spray powder was controlled in 1％-2％. The optimal technology was as follow as wheel pressure of 3.5 MPa， roller speed of 4 r/min and feeding speed of 10 r/min. In verification test， average yield of particle was 69.2％ and angle of repose was 31.5 °. Transfer rate of chlorogenic acid had reached over 92％， and RSD of each index was below 2.53％ （n＝3）. CONCLUSIONS： Each index of particle prepared by optimized accessories formulation and technology shows good reproducibility and feasibility， and the technology is stable and suitable for production.