Objective To investigate the effect of Positive Emotion

Engagement

Relationships

Meaning

and Accomplishment（PERMA）-based positive psychological intervention on self-esteem

stigma

and quality of life in patients with schizophrenia during the rehabilitation period. Methods A total of 120 patients with schizophrenia during the rehabilitation period from April 2021 to March 2022 in the Zhumadian Second People’s Hospital were randomly assigned to the observation group and control group

with 60 cases in each group. Patients in the control group received routine health education intervention

and patients in the observation group PERMA-based positive psychological intervention based on the intervention in the control group. The self-esteem scale（SES）

insight and treatment attitude questionnaire（ITAQ）

Link stigma scale

and schizophrenia quality of life scale（SQLS） were used to assess the self-esteem level

stigma

and quality of life of patients before and after the intervention. Results The SES and ITAQ scores of the two groups after intervention were significantly higher than those before the intervention

and the observation group was significantly higher than the control group（P<0.05）. After the intervention

the perceived Devaluation-Discrimination

secrecy

withdrawal

distancing

challenging

misunderstanding

different from others/feeling shamed dimension scores

and total scores in the Link stigma scale of the patients in the 2 groups were lower than those before the intervention

with the observation group lower than the control group

and the differences were statistically significant（P <0.05）. The scores of psychosocial

motivation and energy

symptoms

and side effects in SQLS after intervention in the 2 groups were lower than those before the intervention

with the observation group lower than the control group

and the differences were statistically significant（P<0.05）. Conclusion PERMA-based Positive psychological intervention can significantly improve the self-esteem

insight

and stigma of patients with schizophrenia during the rehabilitation period

and improve their quality of life.