Objective To investigate the clinical efficacy of high ligation of great saphenous vein combined with endovenous laser in the treatment of varicose veins of lower extremities. Methods A total of 108 patients with varicose veins of lower extremities who were diagnosed and treated in a hospital in Tianjin from January 2020 to September 2021 were selected as the subjects and assigned to the control group（n=54） and the observation group（n=54） by the random number table. The patients in the control group received high ligation of the great saphenous vein. The patients in the observation group received endovenous laser treatment in addition to the treatment in the control group. The clinical efficacy

clinical surgical indicators

incidence rate of complications

Aberdeen Varicose Vein Severity Score（AVVSS） and prognosis were compared between the two groups. Results The overall response rate of the observation group was 98.15%

which was higher than that of the control group（85.19%）

with statistical significance（P<0.05）. The operation time

hospital stay

and intraoperative blood loss in the observation group were shorter than those in the control group

and the differences were statistically significant（P<0.05）. The incidence rate of complications in the observation group was 5.56%

which was lower than that in the control group（22.22%）

and the difference was statistically significant（P<0.05）. The AVVSS of the two groups after treatment were lower than those before treatment

and the observation group was lower than the control group

with statistically significant differences（P <0.05）. The hypopigmentation rate and ulcer healing rate in the observation group were higher than those in the control group after a 3-month follow-up

and the differences were statistically significant（P<0.05）; the difference in the recurrence rate of varicose veins between the two groups was not statistically significant（P>0.05）. Conclusion The high ligation of great saphenous vein combined with endovenous laser treatment is effective in treating varicose veins of lower extremities. It can reduce AVVSS

shorten operation time and hospital stay

and reduce intraoperative blood loss

which is conducive to reducing the risk of complications and improving the prognosis.