Objective To analyze the therapeutic effect of multidisciplinary collaborative care model combined with endoscopic ligation on esophageal variceal bleeding. Methods One hundred and eight patients with esophageal variceal bleeding admitted to a hospital in Luoyang from January 2018 to December 2020 were selected as study subjects and divided into control group（54 cases） and study group（54 cases） according to the order of admission. Patients in both groups were treated with endoscopic ligation. The patients in the control group were given conventional nursing interventions while the patients in the observation group were given multidisciplinary collaborative nursing model interventions

and both groups received nursing care until discharge. The negative emotions

self-management behaviors and self-efficacy scores of patients in the two groups before and after the intervention were compared

and the occurrence of complications in the two groups was compared. Results At discharge

the social psychosocial behavior

eating behavior

therapeutic behavior

somatic activity

and self-efficacy scores were higher in both groups than before intervention

and those in the study group were higher than the control group（P<0.05）; SDS and SAS scores were lower in both groups

and lower in the study group than in the control group（P<0.05）. The incidence of delayed rebleeding and dysphagia in the study group was 5.56%and 5.56%

respectively

which was lower than that in the control group（20.37% and 22.22%

P<0.05）. Conclusion The multidisciplinary collaborative care model combined with endoscopic ligation can improve the self-management behaviors and negative emotions of patients with esophageal variceal bleeding

increase their self-efficacy

and reduce their postoperative complication rates with high safety. Therefore

it is worthy of further clinical study and application.