Objective To investigate the epidemiological characteristics of adverse drug reactions（ADRs） with hesperidin sodium for injection and the factors associated with the occurrence of ADRs. Methods The ADR re-ports of hesperidin sodium for injection in Chongqing from 2014 to 2019 were selected for investigation. Epidemi-ological statistics of 1 391 ADR cases qualified for reporting were collected

and the ADR characteristics of 1 338 ADR reports eligible for inclusion were analyzed using the decision tree method and the association rule method. Results The ADR of hesperidin sodium was correlated with patients’ gender

age

route of administration

and reason for medication. The occurrence of ADRs was mainly concentrated in the 2 periods of 10-30 min and 1-3 d after medication administration. Conclusion The ADR of hesperidin sodium is relatively common in clinical practice

and the causes and characteristics of ADR should be fully understood to ensure the safe and effective clinical use of the drug.