Objective To explore the effect of applying the PBL combined with MOOC teaching mode in the standardized training of general practitioners. Methods Sixty trainees of general practice training who underwent training in a hospital in Guiyang from September 2018 to January 2020 were selected as study subjects. The random number table method was used to divide the trainees into observation and control groups

with 30 cases in each group. The trainees in the control group received a training based on the PBL teaching mode; the trainees in the observation group received a training based on PBL combined with MOOC. At the end of the training

the scores of core competency assessment of general practitioners

subjective experience of training and independent learning ability of general practitioners of the 2 groups were compared. Results The observation group trainees had better interrogation and medical record analysis ability

physical examination and clinical skills

ancillary testing ability

and higher practitioner general and practice scores than the control group

and all differences were statistically significant（P<0.05）. The subjective experience（teaching mode recognition

teaching satisfaction

and knowledge acquisition rate） of the trainees in the observation group was significantly better than that of the control group（P<0.05）. The ratings of self-monitoring and regulation

acquiring and processing information

setting learning goals and plans

self-motivation

and learning beliefs of the participants in the observation group were all higher than those of the control group

and the differences were statistically significant（P <0.05）. Conclusion The application of PBL combined with MOOC in the teaching of general practice training effectively improves the core competencies

self-learning ability and subjective training experience of the trainee; it is worth promoting and wider application.