Objective To explore the influencing factors of spontaneous abortion in pregnant women with polycystic ovary syndrome（PCOS） after treatment. Methods Patients with PCOS after routine treatment from a hospital in Henan Province from June 2019 to July 2020 were selected as the objects of study. The patients with spontaneous abortion were included in the spontaneous abortion group

and the patients without spontaneous abortion were included in the delivery group. The occurrence of spontaneous abortion in all patients was recorded; and the baseline data of patients was enquired and recorded. The possible influencing factors were included in single factor analysis

and then the statistically significant factors were included in Logistic regression analysis. Results Among the 81 pregnant cases after PCOS treatment

25 cases had spontaneous abortion

and the rate of spontaneous abortion was 30.86%（25/81）. The body mass index（BMI） and luteinizing hormone（LH） levels in the spontaneous abortion group were higher than those in the delivery group

and the proportion of insulin resistance in the spontaneous abortion group was significantly higher than that in the delivery group（P<0.05）.The results of Logistic regression analysis showed that high BMI

high LH level and insulin resistance were independent risk factors for spontaneous abortion after PCOS treatment（P<0.05）. Conclusion After PCOS treatment

the risk of spontaneous abortion is higher in pregnant women

and high BMI

high LH level and insulin resistance are independent risk factors of spontaneous abortion. Clinical intervention should be carried out to reduce the risk of spontaneous abortion.