Objective To investigate the therapeutic effect of Nd∶YAG laser combined with triamcinolone acetonide on oral submucous fibrosis（OSF）. Methods One hundred and one patients with OSF treated in a hospital in Liaoyang City from September 2017 to September 2019 were selected and divided into an observation group（49 cases） and a control group（52 cases） using a random number table. Patients in the control group were treated with tretinoin and patients in the observation group were treated with Nd∶YAG laser on the basis of the control group. The clinical efficacy

inflammatory factors levels

mucosal lesion area

blood rheology index

and degree of mouth opening of the two groups were compared before and after treatment. Results The total effective rate of treatment for patients in the observation group was 95.92%

higher than that of 80.77% in the control group

and the difference was statistically significant（χ~2=5.530

P=0.019）. The erythrocyte pressure

low-cut whole blood viscosity

and fibrinogen（FIB） levels were lower in the 2 groups than before treatment

and lower in the observation group than in the control group

with statistically significant differences（P

<

0.05）. After treatment

the serum tumor necrosis factor-α（TNF-α）

interleukin-6（IL-6） and transforming growth factor-β

1

（TGF-β

1

） levels were lower than those before treatment and lower in the observation group than in the control group

and the differences were statistically significant（P

<

0.05）. Oral VAS scores and mucosal lesion area in the two groups were smaller than those before treatment and smaller in the observation group than in the control group

and mouth opening was greater in the observation group than before treatment and that in the control group. The differences were all statistically significant（P

<

0.05）. Conclusion Nd∶YAG laser combined with tretinoin is effective in the treatment of OSF

which helps to reduce the inflammatory response of the patient and improve the blood rheological index and mucosal damage.