Objective To explore the value of applying comprehensive guidance care based on the concept of humanization in patients undergoing modified radical mastectomy for breast cancer. Methods Eighty-one female breast cancer patients treated with modified radical surgery in a hospital in Henan Province from January 2019 to December 2020 were selected and divided into a study group（41 cases） and a control group（40 cases） using the random number table method. Patients in the control group were given conventional care and patients in the study group were given comprehensive guidance care based on the concept of humanization. The Hamilton Anxiety Rating Scale（HAMA）

Hamilton Depression Rating Scale（HAMD）

and Activities of Daily Living（ADL） scores

the occurrence of postoperative complications and nursing satisfaction were compared between the 2 groups before and after surgery. Results The HAMA and HAMD scores of patients in both groups were lower at 14 days after surgery than at 1 day before surgery

and the study group was lower than the control group

and the differences were statistically significant（P

<

0.05）. the scores of advanced ability and basic ability dimensions and total scores in ADLs of patients in both groups were lower at 14 days after surgery than at 1 day before surgery

but the study group was higher than the control group

and the differences were statistically significant（P

<

0.05）. Patient care satisfaction was 97.56% in the study group

which was higher than 82.50% in the control group

and the difference was statistically significant（χ

2

=5.160

P=0.023）. The postoperative complication rate of patients in the study group was 9.76%

which was lower than 20.00% in the control group

but the difference was not statistically significant（χ

2

=1.684

P=0.194）. Conclusion Comprehensive guidance care based on the concept of humanization can effectively reduce negative perioperative emotions and improve the quality of life of patients undergoing radical mastectomy for breast cancer.