Objective To investigate the effects of bifidobacterium triptans treatment on inflammatory factors

intestinal flora and immune function in children with acute infectious diarrhea. Methods One hundred and thirtytwo cases of children with acute infectious diarrhea admitted to a hospital in Henan Province from September 2017 to September 2019 were selected for the study and were divided into a control group and an observation group using the random number table method

with 66 cases in each group. The children in the control group were treated with montelukast

and the children in the observation group were treated with Bifidobacterium triptans

and the clinical efficacy

serum endotoxin

interleukin 6（IL-6）

tumor necrosis factor-α（TNF-α）

C-reactive protein（CRP） levels

intestinal flora levels

and peripheral blood T-lymphocyte subpopulation CD4

+

CD8

+

CD4

+

/CD8

+

ratio levels before and after the treatment were compared between the two groups. Results The total effective rate of treatment for the children in the observation group was 98.48%

which was lower than that of the control group（87.88%）

and the difference was statistically significant（χ

2

=4.293

P=0.038）. Serum endotoxin

IL-6

TNF-α and CRP levels in the two groups were lower than those before treatment and higher in the observation group

and the difference was statistically significant（P

<

0.05）. The serum CD4

+

and CD4

+

/CD8

+

ration levels in the observation group after treatment were higher than those before treatment and higher than those in the control group

and the differences were statistically significant（P

<

0.05）. The levels of intestinal bifidobacteria and B/E of children in the observation group were higher than those in the control group after treatment

and the level of enterobacteriaceae was lower than that in the control group

and the differences were all statistically significant（P

<

0.05）. Conclusion The treatment of acute infectious diarrhea in children with bifidobacterium triptans can suppress the inflammatory reaction

regulate the level of intestinal flora and improve the immune function of the children.