Objective To compare and analyze the effects of compound lidocaine cream and lidocaine on analgesia and hemodynamics on patients with arterial puncture. Methods Eighty-nine elderly patients who underwent invasive arterial blood pressure monitoring in a hospital in Liaoning Province from January 2020 to January 2021 were selected for the study

and the patients were divided into a control group（n=44） and an observation group（n=45） using the random number table method. Before performing arterial puncture

the anesthesiologist gave local infiltration anesthesia with lidocaine to the control group patients. Patients in the observation group were given local anesthesia with compound lidocaine cream for cortical layer. The visual analog scale（VAS） scores of the 2 groups of patients at several time points after puncture were compared. The hemodynamic profiles

including postextrasystolic potentiation（PEP）

cardiac output（CO）

heart rate（HR）

cardiac index（CI）

mean arterial pressure（MAP）

and stroke volume（SV） of patients in the 2 groups at several time points after receiving different protocols of anesthesia were compared. Results There was no statistically significant difference in VAS scores at 4 h

6 h

and 12 h after puncture between the 2 groups（P>0.05）. At the time of puncture

there was no statistically significant difference between the levels of PEP

CO

HR

CI

MAP

and SV in the 2 groups（P>0.05）. At 4 h after puncture

the levels of HR

CI

CO

and MAP in the 2 groups were lower than those at the time of puncture

while those in the observation group were higher than those in the control group

and the differences were all statistically significant（P<0.05）. At 4 h after puncture

PEP was shorter than at the time of puncture in the 2 groups

while it was longer in the observation group than in the control group

and the difference was statistically significant（P<0.05）. At 4 h after puncture

SV was smaller in the 2 groups than at the time of puncture

while it was larger in the observation group than in the control group

and all differences were statistically significant（P<0.05）. Conclusion Both compound lidocaine cream and lidocaine local infiltration anesthesia can be used for patients with invasive arterial blood pressure monitoring

but compared with lidocaine local infiltration anesthesia

compound lidocaine cream is more effective and safer for maintaining hemodynamic stability of patients and has higher value for clinical promotion.