Objective To investigate the clinical value of glucose fluctuation in the evaluation of microvascular complications of type 2 diabetes. Methods Ninety-six patients with type 2 diabetes treated in a hospital in Zhengzhou from September 2018 to September 2019 were divided into abnormal group（n=43） and normal group（n=53） according to the abnormal range of mean amplitude of glycemic excursions（MAGE）. The relationship between MAGE and microvascular complications was analyzed. Results The incidences of coronary heart disease

diabetic foot

diabetic nephropathy

diabetic retinopathy and hypertension in the abnormal group were significantly higher than those in the normal group（P<0.05）. There were significant differences in the distribution of e GFR within and between the two groups（P<0.05）. There was no significant difference in the diameter of superior temporal artery and superior temporal vein between the two groups（P>0.05）

but the AVR in the abnormal group was significantly lower than that in the normal group（P<0.05）. Logistic multiple regression analysis showed that microalbuminuria

hypertension

EGFR and AVR were independent risk factors for abnormal fluctuation of MAGE in patients with diabetes mellitus（P<0.05）. Conclusion MAGE is closely related to the occurrence of microvascular complications in patients with type 2 diabetes. To some extent

MAGE can be used as an important index to evaluate the incidence of retinopathy and nephropathy in patients with type 2 diabetes.