Objective To analyze the probability and change trend of premature death of four major chronic disea-ses（cardiovascular and cerebrovascular diseases

malignant tumors

chronic respiratory diseases and diabetes） in Changshou District of Chongqing from 2011 to 2019 in order to provide scientific basis for the prevention and con-trol of major chronic diseases. Methods The death cause surveillance data of the whole population in Changshou District of Chongqing from 2011 to 2019 were analyzed. SPSS 22.0 was used to calculate the crude population mortality rate

standardized mortality rate and constituent ratio

premature death probability and annual percent change（APC）. Results There was no significant difference in the change trend of crude mortality rate and standardized mortality rate of major chronic diseases in Changshou District from 2011 to 2019（P>0.05）. The probability of prema-ture death of major chronic diseases in Changshou District decreased from 17.11% in 2011 to 12.29% in 2019. The APC was-2.76%

and the difference was statistically significant（P<0.05）. The probability of premature death of major chronic diseases in males was higher than that in females in each year

and the difference was statistically signifi-cant（P<0.05）. The probability of premature death fluctuated in males ranged from 16.93% to 21.90%

with the APC of-1.49%

and there was no significant difference in the change trend（P>0.05）. The probability of premature death in females decreased from 13.23% in 2011 to 7.48% in 2019

with the APC of-5.07%

and the difference was statistically significant in the change trend（P<0.05）. The probability of premature death of cardiovascular and cerebro-vascular diseases in Changshou District showed a downward trend with the APC of-4.78%

and the difference was statistically significant（P<0.05）.The probability of premature death of chronic respiratory diseases decreased at an av-erage annual rate of 4.97%（P<0.05）. There was no significant difference in the change trend of premature death probability between malignant tumor and diabetes（P>0.05）. Conclusion From 2011 to 2019

the probability of pre-mature death of major chronic diseases in Changshou District decreased significantly. However it was still at a high level

thus

we should focus on strengthening the prevention and treatment of malignant tumors and diabetes in Changshou District.