Objective To explore the efficacy of Zhike Juhong Koufuye combined with acetylcysteine effervescent tablets in the treatment of acute exacerbation of chronic obstructive pulmonary disease（COPD）.Methods A total of 90 patients with acute exacerbation of COPD in our hospital from January 2018 to December 2019 were randomly divided into control group and observation group

with 45 cases in each group.The patients in the control group were treated with acetylcysteine effervescent tablets on the basis of routine symptomatic treatment

and the patients in the observation group were treated with Zhike Juhong Koufuye on the basis of the control group.The clinical efficacy

adverse reactions during treatment

pulmonary function before and after treatment

CAT score and 6 min walking distance were compared between the two groups.Results The total effective rate of patients in the observation group was 93.33%

which was higher than that in the control group（82.22%）

and the difference was statistically significant（P

<

0.05）.Before treatment

there was no significant difference in forced expiratory volume in the first second（FEV

1

）

forced vital capacity（FVC）

FEV

1

/FVC

CAT

and 6 min walking distance between the two groups（P

>

0.05）.After treatment

FEV

1

FVC

FEV

1

/FVC

CAT

and 6 min walking distance in the two groups were significantly higher than that before treatment（P

<

0.05）

and those in the observation group were significantly higher than those in the control group（P

<

0.05）.The incidence of adverse reactions in the observation group was 6.67%

which was lower than that in the control group（22.22 %）

and the difference was statistically significant（P

<

0.05）.Conclusion Zhike juhong koufuye combined with acetylcysteine effervescent tablets is effective in the treatment of acute exacerbation of COPD

and can help to improve the lung function of the patients.