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非雌激素药物联合局部抗炎药治疗绝经后萎缩性阴道炎的效果
Effect of non-estrogenic drugs combined with topical anti-inflammatory drugs in the treatment of postmenopausal atrophic vaginitis
- 保健医学研究与实践 2021年18卷第3期 页码：116-120
- 作者机构：
1. 佳木斯市妇幼保健院产后康复科
2. 佳木斯市妇幼保健院产科
3. 佳木斯市妇幼保健院妇科
- 作者简介：
- 基金信息：
DOI：
中图分类号： R711.31纸质出版日期：2021，
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郑红霞, 徐立婧, 曲春尧, 等. 非雌激素药物联合局部抗炎药治疗绝经后萎缩性阴道炎的效果[J]. 保健医学研究与实践, 2021,18(3):116-120.
Zheng Hongxia, Xu Lijing, Qu Chunyao, et al. Effect of non-estrogenic drugs combined with topical anti-inflammatory drugs in the treatment of postmenopausal atrophic vaginitis[J]. Health Medicine Research and Practice, 2021,18(3):116-120.
郑红霞, 徐立婧, 曲春尧, 等. 非雌激素药物联合局部抗炎药治疗绝经后萎缩性阴道炎的效果[J]. 保健医学研究与实践, 2021,18(3):116-120. DOI：
Zheng Hongxia, Xu Lijing, Qu Chunyao, et al. Effect of non-estrogenic drugs combined with topical anti-inflammatory drugs in the treatment of postmenopausal atrophic vaginitis[J]. Health Medicine Research and Practice, 2021,18(3):116-120. DOI：
摘要
目的探讨非雌激素药物联合局部抗炎药治疗绝经后萎缩性阴道炎的效果。方法选取2018年5月-2020年3月黑龙江省某医院收治的97例绝经后萎缩性阴道炎患者为研究对象
采用随机数字表法分为对照组(32例)、非雌激素联合组(33例)、雌激素联合组(32例)。对照组患者给予局部抗炎药单药治疗
非雌激素联合组患者在对照组基础上联用重组人源胶原蛋白阴道凝胶
雌激素联合组患者在对照组基础上外用雌激素
均治疗2个月。比较3组患者治疗前后阴道症状和体征评分、酸碱平衡性、性激素水平、阴道细胞成熟情况、炎症因子水平。结果治疗前
3组患者阴道症状和体征评分比较
差异无统计学意义(P>0.05);治疗后
3组患者阴道症状和体征评分均低于治疗前
差异均有统计学意义(P<0.05);治疗后
3组患者阴道症状和体征评分经方差分析及两两比较发现
非雌激素联合组<雌激素联合组<对照组
差异有统计学意义(P<0.05)。治疗前
3组患者阴道p H值比较
差异无统计学意义(P>0.05);治疗后
3组患者阴道p H值均低于治疗前
差异均有统计学意义(P<0.05);治疗后
3组患者阴道p H值经方差分析及两两比较发现
非雌激素联合组<雌激素联合组<对照组
差异有统计学意义(P<0.05)。3组患者治疗前及治疗后卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)水平比较
差异均无统计学意义(P>0.05)。治疗前
3组患者阴道脱落细胞成熟指数比较
差异无统计学意义(P>0.05);治疗后
3组患者阴道脱落细胞成熟指数均高于治疗前
差异均有统计学意义(P<0.05);治疗后
3组患者阴道脱落细胞成熟指数经方差分析及两两比较发现
非雌激素联合组>雌激素联合组>对照组
差异有统计学意义(P<0.05)。治疗前
3组患者血清C反应蛋白(CRP)及白介素-6(IL-6)水平比较
差异无统计学意义(P>0.05);治疗后
3组患者血清CRP水平均高于治疗前
IL-6水平均低于治疗前
差异均有统计学意义(P<0.05);治疗后
3组患者血清CRP及IL-6水平经方差分析及两两比较发现
非雌激素联合组<雌激素联合组<对照组
差异有统计学意义(P<0.05)。结论非雌激素药物联合局部抗炎药可有效改善绝经后萎缩性阴道炎患者阴道症状
调节阴道酸碱平衡
有助于促进阴道细胞成熟及减轻炎症反应
且对性激素水平影响较小。
Abstract
Objective To investigate the effect of non-estrogenic drugs combined with topical anti-inflammatory drugs in the treatment of postmenopausal atrophic vaginitis.Methods Ninety-seven patients with postmenopausal atrophic vaginitis admitted to a hospital in Heilongjiang from May 2018 to March 2020 were selected for the study and divided into a control group（32 cases）
a non-estrogen combination group（33 cases）and an estrogen combination group（32 cases） using a random number table.Patients in the control group were given topical antiinflammatory drugs as monotherapy
patients in the non-estrogen combination group were treated with recombinant human-derived collagen vaginal gel on the basis of the control group
and patients in the estrogen combination group were treated with topical on the basis of the control group
all for 2 months.The vaginal symptoms and signs scores
acid-base balance
sex hormone levels
vaginal cell maturation
and inflammatory factor levels were compared before and after treatment in the three groups.Results Before treatment
there was no statistically significant difference in the scores of vaginal symptoms and signs among the 3 groups（P>0.05）;after treatment
the scores of vaginal symptoms and signs were lower than those before treatment in all 3 groups-and the difference was statistically significant（P<0.05）;after treatment
analysis of variance and two-by-two comparison revealed that the scores of vaginal symptoms and signs in the 3 groups were
ranked from the lowest to the highest
non-estrogen combination group
estrogen combination group
and control group.The difference was statistically significant（P<0.05）.Before treatment
there was no statistically significant difference in vaginal pH among the three groups（P>0.05）;after treatment
vaginal pH was lower than before treatment in all three groups
and the difference was statistically significant（P<0.05）;after treatment
analysis of variance and two-by-two comparison ranked the three groups
in terms of vaginal pH
as follows:that the non-estrogen combination group
estrogen combination group
and control group.The difference was statistically significant（P<0.05）.The differences in follicle-stimulating hormone（FSH）
luteinizing hormone（LH） and estradiol（E2） levels between the three groups before and after treatment were not statistically significant（P>0.05）.Before treatment
there was no statistically significant difference in vaginal exfoliative cell maturation index between the three groups（P>0.05）;after treatment
the vaginal exfoliative cell maturation index was higher in all three groups than before treatment
and the difference was statistically significant（P<0.05）;after treatment
analysis of variance and two-by-two comparison revealed that the vaginal exfoliative cell maturation indices of the three groups were
in descending order
non-estrogen combination group
estrogen combination group
and control group
and the difference was statistically significant（P>0.05）.The difference was statistically significant（P <0.05）.Before treatment
there was no statistically significant difference between the serum C-reactive protein（CRP） and interleukin-6（IL-6） levels of the three groups（P>0.05）;after treatment
the serum CRP levels of the three groups were higher than before treatment
and the IL-6 levels were lower than before treatment
and the difference was statistically significant（P<0.05）;after treatment
it was found by ANOVA and two-by-two comparison that the serum CRP and IL-6 level-s of the three groups were higher than before treatment
and the difference was statistically significant（P<0.05）.After treatment
by ANOVA and two-by-two comparison
it was found that the serum CRP and IL-6 levels in the three groups were
in ascending order
non-estrogen combination group
estrogen combination group
and control group
and the difference was statistically significant（P <0.05）.Conclusion Non-estrogenic drugs combined with topical anti-inflammatory drugs can effectively improve vaginal symptoms in postmenopau sal patients with atrophic vaginitis
regulate vaginal acid-base balance
help promote vaginal cell maturation and reduce inflammatory response
and have less effect on sex hormone levels.
关键词
非雌激素药物局部抗炎药萎缩性阴道炎阴道症状激素水平
Keywords
Non-estrogenic drugsTopical anti-inflammatory drugsAtrophic vaginitisVaginal symptomsHormone levels
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