Study on the correlation between cerebral oxygen saturation during radical resection of elderly lung cancer and postoperative neuro-cognitive dysfunction
ZHAO De-cai, SUN Yu-hong, LIU Wei. Study on the correlation between cerebral oxygen saturation during radical resection of elderly lung cancer and postoperative neuro-cognitive dysfunction[J]. null, 2021,(11):947.
ZHAO De-cai, SUN Yu-hong, LIU Wei. Study on the correlation between cerebral oxygen saturation during radical resection of elderly lung cancer and postoperative neuro-cognitive dysfunction[J]. null, 2021,(11):947.DOI:
比较2组患者不同时间点的SctO2水平。采用受试者工作特征(ROC)曲线分析术中SctO2对患者出现PNCD的预测价值。采用Logistic回归模型分析老年肺癌根治术后出现PNCD的危险因素。结果 2组患者麻醉前、麻醉后手术开始前SctO2水平比较,差异无统计学意义(P>0.05)。PNCD组患者手术开始30 min及60 min的SctO2水平低于非PNCD组(P<0.05)。ROC曲线显示,手术开始30 min SctO2水平预测患者出现PNCD的最佳截断值为63.29%,曲线下面积为0.812(95%CI:0.718~0.906),灵敏度和特异度分别为71.43%、65.22%;手术开始60 min SctO2水平预测患者出现PNCD的最佳截断值为62.35%,曲线下面积为0.822(95%CI:0.722~0.923),灵敏度和特异度分别为76.84%、69.57%。Logistic回归模型分析结果显示:年龄>70岁、麻醉时间及手术时间较长、超敏C反应蛋白(hs-CRP)水平较高、手术开始30 min SctO2<63.29%、手术开始60 min SctO2<62.35%是患者出现PNCD的独立危险因素(P<0.05)。结论 术中SctO2水平较低是PNCD发生的独立危险因素之一,其水平可用于预测老年肺癌根治术后出现PNCD的情况。