The Wnt signaling pathway regulates the development and homeostasis of many tissues，and controls embryonic develop－ment and adult homeostasis. Abnormal signals in the Wnt signaling pathway not only cause developmental defects，but also are closely related to the occurrence of various cancers. In recent years，Wnt signaling pathway has been found to be associated with the formation，migration and apoptosis of osteosarcoma. Secreted frizzled-related protein 1（SFRP1） is considered to be a type of Wnt pathway modu－lator because its partial structure is highly homologous to the frizzled（FZD） protein receptor of Wnt signaling pathway，which regulates the Wnt signaling pathway in osteosarcoma. This article reviews the regulation of SFRP1-Wnt signaling pathway in osteosarcoma.