Objective：To study the correlation and clinical significance of the serum anti-Müllerian hormone（AMH） and inhibin B（INHB） levels of girls with the progression of central precocious puberty（CPP），and point out new directions for the diagnosis and treatment of rapidly progressive CPP（RP-CPP） girls. Methods：A total of 55 girls with CPP who were diagnosed in Department of Endocrinology，Genetics and Metabolism of Jiangxi Provincial Children’s Hospital were included in our research. Then，32 of them were divided into RP-CPP group（n=32） and 23 of them into SP-CPP group（n=23） according to the progressive index. Meanwhile，30 immature and age-matched girls were collected as the normal control group. Results：The serum levels of AMH in RP-CPP，SP-CPP and control groups were significantly different（P<0.05）. Significant differences were founded between RP-CPP group and control group and also between SP-CPP and control group（P<0.05），while no statistical differences were found between RP-CPP group and SP-CPP group（P >0.05）. AMH levels of girls were significantly negatively correlated with basal-LH，basal-FSH，peak-LH，and peak-FSH in the RP-CPP group. Conclusion：Our results suggest that AMH and INHB are associated with the progress of RP-CPP girls，meanwhile they are potential laboratory indicators to identify RP-CPP girls rapidly in clinical work.