Aqueous humor is produced by the ciliary body. It is an important nutrient and circulating substance in the eye. It has the function of maintaining intraocular pressure. In recent years，many scholars have detected changes in cytokine levels in aqueous humor in eye diseases such as glaucoma，uveitis，and age-related macular degeneration. Glaucoma is the first irreversible blinding disease worldwide，but the specific mechanism of its occurrence is not clear. Some researchers have suggested that changes in cytokines in aqueous humor may play an important role in the occurrence and development of glaucoma. This article reviews and analyzes the re－cent relevant literature，and it reviews the changes of several common cytokines in the aqueous humor of glaucomatous patients and their role in glaucoma.