Protein kinase Cβ（PKCβ） is a classical PKC subtype，which can be induced and activated by hyperglycemia，leading to a variety of diabetes complications. Activated PKCβ causes endothelial dysfunction，induces white blood cell adhesion，regulates the ex－pression of cytokines and transcription factors through downstream signaling pathways，leading to macrovascular complications，such as atherosclerosis，cardiomyopathy and apoplexy and microvascular complications，such as diabetic nephropathy，retinopathy and pe－ripheral neuropathy. In this paper，the role of PKCβ in diabetic complications and its related research in clinical treatment were described.