As the coronavirus disease 2019（COVID-19） develops，the corresponding strategy has been gradually completed. As one of the biggest local general hospitals in Chongqing，our hospital not only shoulder the prevention and treatment of COVID-19 during the epidemic period，but also undertake a large number of routine diagnosis and treatment activities in the outpatient department. For ensuring the safety of patients，the work pressure in outpatient department is prominent. In the end，the outpatient department of our hospital has achieved the goal of zero missed inspection，zero missed report and zero infection by improving the organizational struc－ture，reasonably arranging human resource，strictly controlling epidemic prevention materials，rearranging the protective and isolation environment，optimizing the treatment process，and strengthening the prevention and control health education of COVID 19.