Objective：This study intends to construct an emergency guarantee system of intracranial infection for epidemic prevention and control，aiming at providing references and guidelines for the government and medical institutions to improve the efficiency of treating intracranial infection patients in the clinical practice during coronavirus disease 2019（COVID-19） epidemic. Methods：This study constructed the emergency treating framework of intracranial infection by integrating experience and resources from all clinical departments，aiming at the key and difficult problems faced by emergency guarantee system during COVID-19 outbreak. Results：The main problem of formulating emergency guarantee system was to efficiently identify whether the intracranial infection was caused by COVID-19，so as to improve the efficiency of diagnosing and treating of intracranial infection by ways of strengthening the manage－ment of inpatient ward and standardizing the diagnosis and treatment process of patients in the emergency observation，aiming at as－sisting medical staffs during the clinical practice. Conclusion：The emergency guarantee system of intracranial infection for epidemic prevention and control during outbreak of COVID-19 depends on various resources and experience from all clinical departments.