Objective：To investigate the association between distance of pregnant women’s living place to main road and various ad－verse pregnancy outcomes. Methods：This is a prospective cohort study in Chongqing. A questionnaire survey was conducted to collect information of 703 pregnant women who received the first prenatal examination in the First Affiliated Hospital of Chongqing Medical University from September 2015 to August 2016. The pregnant women were divided into two groups according to the distance between the residence and the main road：a total of 618 pregnant women lived ≥250 meters from the main road and a total of 85 pregnant women lived <250 meters. The pregnancy outcomes of two groups were followed up and were enrolled in multivariate analysis. The logistic regression was used to analyze the relationship between residential proximity to main road and premature birth，gesta－tional diabetes mellitus，preeclampsia，premature rupture of mem－branes，low birth weight and macrosomia，respectively. Multiple linear regression was used to explore the association among residential proximity to main road and neonatal weight and body length. Results：Taking the pregnant woman’s residence at a distance of ≥250 meters from the main road as control，after adjusting the basic demographic characteristics of pregnant women，the distance <250 meters was not a risk factor for preterm birth（OR=0.669，95%CI=0.153-2.972，P=0.593），gestational diabetes mellitus（OR=0.784，95%CI=0.454-1.353，P=0.382），preeclampsia（OR=1.650，95%CI=0.454-5.991，P=0.447），premature rupture of membranes（OR=1.120，95%CI=0.672-1.867，P=0.664），low birth weight（OR=1.626，95%CI=0.455-5.809，P=0.454） and macrosomia（OR=1.932，95%CI=0.763-4.890，P=0.165），nor did it influence the weight（OR=0.037，95%CI=-49.746-146.518，P=0.333） and length（OR=0.009，95%CI=-0.350-0.445，P=0.813） of the newborn. Conclusion：The distance between living place of pregnant women and the main road <250 meters is not a risk factor of adverse pregnancy outcomes.