Objective To investigate the medication rule of traditional Chinese medicine（T.C.M）prescriptions containing Radix Rehmanniae in the treatment of systemic lupus erythematosus（SLE）based on data mining.Methods CNKI

VIP

WanFang Data

and CBM were searched for the articles on TCM prescriptions containing Radix Rehmanniae in the treatment of SLE. A database was established

and descriptive statistics

association rule

and decision tree model were used to analyze the medication rule of prescriptions. Results A total of 203 SLE cases treated with TCM prescriptions containing Radix Rehmanniae were screened out in this study

involving 264 drugs. The top five types of drugs in terms of frequency were heat-clearing drugs

deficiency-tonifying drugs

blood-activating and stasis-resolving drugs

heat-clearing and liver-calming drugs

and diuresis-inducing and dampness-draining drugs

and Radix Rehmanniae

Radix Glycyrrhizae

Salvia Miltiorrhiza

Concha Ostreae

and Poria Cocos had the highest frequency in each type. The most frequently used drug combination was Radix Rehmanniae-Cortex Moutan Radicis. The association rules with support > 25% and confidence > 80% included Radix Rehmanniae-Cornu Bubali

Radix Rehmanniae-Radix Scrophulariae

and Radix Rehmanniae-Lonicera Japonica

and the complex network diagram of association rules showed the closest association between Radix Rehmanniae

Cortex Moutan Radicis

Radix Scrophulariae

Radix Glycyrrhizae

Radix Paeoniae Rubra

and Artemisia Apiacea.The decision tree with Radix Rehmanniae as a dependent variable showed the important position of Cortex Moutan Radicis

prepared Radix Rehmanniae

Radix Scrophulariae

Coix Seed

Poria Cocos

Arnebia Root

Cortex Lycii Radicis

Achyranthis Bidentatae Radix

and Rhizoma Anemarrhenae in compatibility. Conclusion Vital Qi-strengthening and pathogen-eliminating drugs are mainly used in TCM prescriptions containing Radix Rehmanniae for the treatment of SLE. Liver-kidney Yin is nourished to strengthen vital Qi

and heat-clearing

blood-cooling

and detoxicating drugs are used to eliminate pathogens

with the combination of blood-activating and stasis-resolving drugs

heat-clearing and liver-calming drugs

and diuresis-inducing and dampness-draining drugs.