Objective:To determine the expression of membrane-associated RING-CH 2（MARCH2）and nuclear factor-kappa B（NF-κB）in invasive breast cancer tissues and adjacent normal tissues

and to explore the relationship between the expression of MARCH2 and NF-κB and the clinicopathological parameters of invasive breast cancer.Methods:We collected cancer tissues and normal breast tissues（more than 3 cm from the edge of the cancer）from 40 patients with invasive breast cancer who underwent surgical treatment from January to December 2018 in Zigong Fourth People’s Hospital.The immunohistochemical method EnVision was used to label MARCH2 and NF-κB in the tissues.Results:MARCH2 was positive in 36（90.0%）of the 40 cancer tissues

and in 7 adjacent normal tissues（χ

2

= 42.288

P

<

0.05）.NF-κB was positive in 30（75.0%）cancer tissues

and in 5 adjacent normal tissues（χ

2

= 31.746

P

<

0.05）.There was a moderate positive correlation between the expression of the two proteins（r = 0.577

χ

2

= 13.333

P

<

0.01）.Conclusion:MARCH2 and NF-κB are highly expressed in invasive breast cancer tissues.The development and progression of breast cancer may be related to the high expression of MARCH2

and NF-κB may be an important signaling pathway.