Objective: To investigate the correlation between high sensitive C-reactive protein（hs-CRP） level and cardiac function in patients with chronic heart failure（CHF） complicated by atrial fibrillation. Methods: A total of 215 patients with heart failure admitted to our hospital from March 2014 to June 2016 were enrolled as subjects.According to electrocardiography（ECG）/24-hour ambulatory ECG and the hs-CRP level

patients were divided into CHF with sinus rhythm group

CHF with atrial fibrillation group

low hs-CRP group（≤ 9.9 mg/L）

and high hs-CRP group（> 9.9 mg/L）. A correlation analysis was performed on the hs-CRP level and cardiac function in CHF complicated by atrial fibrillation. Results: Compared with the low hs-CRP group

the high hs-CRP group had a significantly higher N-terminal pro-brain natriuretic peptide（NT-proBNP） level（P < 0.01）

a significantly higher New York Heart Association（NYHA） grade（P < 0.05）

and a significantly lower left ventricular ejection fraction（LVEF）（P <0.01）. Compared with the CHF with sinus rhythm group

the CHF with atrial fibrillation group had significantly higher NT-proBNP level（P < 0.01）

hs-CRP level（P < 0.01）

and NYHA grade（P < 0.01） but a significantly lower LVEF（P < 0.05）. The hs-CRP level was negatively correlated with LVEF（r =-0.400

P < 0.05） but positively correlated with the NT-proBNP level（r = 0.338

P < 0.05）. Conclusion: Patients with heart failure complicated by atrial fibrillation have a high hs-CRP level and a strong inflammatory response

which result in poor cardiac function and severe disease.