Objective: To analyze the effect of topical application of tranexamic acid on reducing blood loss during and after parotid gland tumor surgery. Methods: A total of 160 patients who had undergone unilateral parotid gland tumor surgery or total parotidectomy from January 2016 to January 2018 and met the inclusion criteria were randomly divided into control group and observation group

with 80 patients in each group. Patients in the observation group were topically injected（at the incision） with a solution of 2 g tranexamic acid in 100 mL physiological saline and underwent hemostasis with gauze soaked in the above solution; patients in the control group underwent hemostasis with gauze soaked in physiological saline. The intraoperative blood loss

postoperative drainage and blood transfusion were recorded. PT

APPT and FIB were checked 2 hours after operation

and blood routine was checked24 hours after operation. Results: There were significant differences between the observation group and the control group in intraoperative blood loss and total postoperative blood loss（P < 0.05）. No postoperative blood transfusion occurred in either group

and the postoperative hemoglobin concentration and hematocrit were significantly lower in the control group than in the observation group（P < 0.05）. There were no significant differences between the two groups in postoperative coagulation markers and blood transfusion rate（P > 0.05）. Conclusion: The topical application of tranexamic acid in parotid gland tumor surgery is effective and safe. It can significantly reduce intraoperative and postoperative blood loss and lower the risk of anemia-related complications caused by perioperative blood loss.Therefore

it holds promise for clinical application.