Oxidative stress is involved in regulating a series of life processes including cell proliferation

differentiation

and death

and it is considered to be an important influencing factor for many diseases. Ca2 +signals are known to play an important role in the regulation processes

yet it is not clear how oxidative stress affects Ca2+signals. The ORAI/STIM channel

the main molecular component of the store-operated calcium channel widely distributed in the cell membrane

contributes to regulation of intracellular calcium homeostasis. Recent studies have demonstrated that STIM1 is an important oxidative stress receptor

participating in regulation of intracellular calcium signals by oxidative stress under physiological or pathophysiological conditions. Numerous studies have shown that oxidative stress is essential in the pathogenesis of cardiovascular and cerebrovascular diseases. However

the association of oxidative stress with ORAI/STIM and related regulation mechanisms remain controversial. Therefore

it is of great significance and medical value to further clarify the relationship between ORAI/STIM-mediated calcium signals and oxidative stress. This review summarizes the mechanisms by which oxidative stress regulates ORAI/STIM-mediated storeoperated calcium entry and relevant research progress in the development and progression of cardiovascular diseases.