was widely used to regulate various physiologi-cal processes.In addition to its classical roles in bone metabolism
epidemiological
preclinical
and cellular re-searches during the last decades
which revealed that vitamin D may play a key role in the prevention and treat-ment of many extra-skeletal diseases such as cancer. Metabolism and functions of Vitamin D are dysregulated in many types of cancer
which contribute to the development and progression of cancer
suggestiong that vitamin D may be an anti-tumor agent. Therefore
understanding the anti-tumor role of vitamin D in cancer will be crucial for the development of vitamin D-based cancer therapy.