Objective To investigate the impact of viral hepatitis infections（including hepatitis A

B

C

D

and E infection）on the risk of Parkinson′s disease（PD）.Methods Literatures on the relationship between viral hepatitis and the risk of PD from January 1965 to October 2019 were obtained by searching in Chinese and English databases.After screening the literatures

quality evaluation was performed and data such as odds ratio（OR）and95%confidence interval（95% CI）were extracted.Meta-analysis was performed using STATA 12.0.Sensitivity analysis and meta-regression analysis were used to find the source of heterogeneity.Publication bias was assessed using the trim-and-fill method.Results A total of 7 articles were included for study.The analyses suggested that hepatitis C virus（HCV）infection is a risk factor for PD（OR=1.19

95%CI=1.01～1.41

P=0.035）

anti-HCV treatment can reduce the risk of PD（OR=0.67

95%CI=0.57～0.79

P<0.001）

and that hepatitis B virus（HBV）infection is not associated with the risk of PD（OR=0.96

95% CI=0.72～1.28

P=0.781）.Conclusion HCV infection may increase the risk of PD

which can be reduced via anti-HCV treatment.Therefore

it is necessary to pay attention to the clinical screening and treatment of patients with HCV infection

so as to reduce the incidence of PD and relieve the economic burden for both the patients and the whole society.