Objective To investigate the clinical features of streptococcus pneumococcal（SP）meningitis in children and the resistance of SP strains.Methods A total of 16 children with SP meningitis who were hospitalized in a hospital in Henan province from March 2013 to October 2018 were enrolled.The clinical data of the subjects were collected

and their clinical characteristics and drug resistance of SP strains were analyzed.Results There were seven subjects≤1 year old and nine subjects

>

1 year old;the course of disease was（4.24±4.76）d.All subjects had high fever（T

>

38.5℃）

eight subjects developed systemic convulsions

and 10 had severe disturbances such as coma and lethargy.13 subjects had abnormal leukocyte counts

9 had cerebrospinal fluid pressure（CFP）

>

200 mmH

2

O（1 mmH

2

O=9.806 Pa）

10 had brain natriuretic peptide（BNP）

>

1 000 pg/mL

13 had hyponatremia

and 10 had hypocalcemia.The sequelae:four cases of hydrocephalus combined with subdural effusion

three cases of epilepsy

three cases of physical activity disorder and two cases of coma.Prognosis:11 subjects were cured and discharged

three subjects died

and two were discharged automatically.The proportion of subjects with poor prognosis who had abnormal leukocyte counts

hypocalcemia

hyponatremia

high BNP levels

and high CFP levels was significantly higher than those with better prognosis.The drug resistance analysis of the isolated SP strains showed that the resistance rates of SP to clindamycin

erythromycin

tetracycline and compound sulfonamide were all higher than 80.00%

while those of SP to meropenem

cefepime

quinupristin/dalfopristin were low（all at 6.25%）

and vancomycin-

tellthromycin-

linezolid-

and levofloxacin-resistant strains were not found.Conclusion Children with SP meningitis are critically ill and have a high incidence of sequelae.The abnormal degree of laboratory findings has a certain significance for prognosis.Besides

SP is highly resistant to commonly used antibiotics in pediatric clinics

so they should be applied with caution.