Objective To investigate the relationship between blood uric acid level and diabetes incidence among faculty members of a college in Beijing.Methods From 2006 to 2016

follow-up observations were performed on the faculty members who had participated in the 2006 physical examination with a fasting blood glucose <7.0 mmol/L

no history of diabetes and had not used hypoglycemic drugs.By the end of 2016

a total of 1 595 subjects were enrolled.The subjects were divided into several groups according to their gender

the prevalence of hypertension and the level of serum uric acid

and the effects of different blood uric acid levels on new-onset diabetes were analyzed.Results Among the groups of non-hypertensive female subjects with different uric acid levels

the differences in all the indices of blood pressure

body mass index（BMI）

blood glucose and blood lipid levels were statistically significant except that of high-density lipoprotein cholesterol（HDL-C）（P<0.05）;among the hypertensive female subjects

the differences in triglyceride（TG）and HDL-C levels in different uric acid groups were statistically significant（P<0.05）.Among the non-hypertensive male subjects

the differences in BMI

serum cholesterol（TC）

TG and HDL-C levels in different uric acid groups were statistically significant（P<0.05）;among the hypertensive male teachers

the difference in the BMI and TG levels in different uric acid groups were statistically significant（P<0.05）.As of the end of 2016

there were 78 new cases of diabetes in the study

with an incidence of 5.00/1 000 person-years.Starting from uric acid group 2（female:uric acid 186 to<218μmol/L;male:uric acid 233 to<274μmol/L）of non-hypertensive subjects

with the gradual increase of uric acid level

the diabetes incidence rate also increased

but the difference was not statistically significant（P>0.05）.In addition

there was no significant difference in the incidence of diabetes among hypertensive subjects in different uric acid groups（P>0.05）

but among the hypertensive subjects

male and female alike

the diabetes incidence was highest in uric acid group 3（female:218 to<249μmol/L;male:274 to<313μmol/L）

which were 18.81/1000 person-years（male）and 17.00/1 000 person-years（female）

respectively.Conclusion When the blood uric acid level is 218 to<249μmol/L in female hypertensive patients and 274 to<313μmol/L in male hypertensive patients

the risk of diabetes may increase.