Objective To investigate the effects of fecal microbiota transplant（FMT）combined with lactulose on the gastrointestinal function

mental state and quality of life in patients with intractable functional constipation.Methods 100 patients with intractable functional constipation diagnosed and treated from January 2017 to December 2018 in a hospital in Shenyang were selected as study subjects.The patients were divided evenly into observation group and control group by random number table.Both groups were given oral lactulose

while the observation group was treated with FMT in addition.After treatment

the recovery of gastrointestinal function

changes in the levels of motilin（MTL）

substance P（SP）

vasoactive intestinal peptide（VIP）and the scores of Knowles Eccersley Scott Symptom（KESS）scoring system

Patient Assessment of Constipation Quality of Life（PAC-QOL）questionnaire

Self-Rating Anxiety Scale（SAS）and Self-Rating Depression Scale（SDS）in the two groups were compared.Results The time of first anus exhaust

return of bowel sound and first independent defecation in the observation group were（11.42±2.65）h

（47.04±12.11）h and（60.38±3.92）h

respectively.They were significantly shorter than those in the control group

which were（23.58±2.49）h

（92.87±18.87）h and（95.51±18.75）h

respectively（P<0.05）.After treatment

the levels of MTL

SP and VIP in the observation group were（239.42±40.39）pg/mL

（45.03±5.93）pg/mL and（12.18±2.57）pg/mL

respectively

and those in the control group were（195.83±39.46）pg/mL

（36.72±6.02）pg/mL

（15.74±2.08）pg/mL

respectively.The MTL and SP levels in the observation group were significantly higher than those in the control group

while the VIP level was significantly lower（P<0.05）.The scores of KESS

PAC-QOL

SAS and SDS in the observation group were 12.67±6.85

62.35±20.48

40.61±5.46

and 39.75±6.11

respectively.All scores were significantly lower than those in the control group

which were 17.21±7.24

83.51±21.05

45.82±6.73

and46.41±5.38

respectively（P<0.05）.Conclusion Fecal microbiota transplant combined with lactulose in the treatment of intractable functional constipation not only maintains sufficient water in the intestine

but also improves the coordination and contraction of the anorectal and rectal compliance

thus shortening the time of first anal exhaust

return of bowel sound and first independent defecation.It also relieves the bad mood of patients and improves their quality of life.