不同剂量比索洛尔对充血性心力衰竭患者心率的影响

李玥; 尚伟; 徐中林

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不同剂量比索洛尔对充血性心力衰竭患者心率的影响

论著_临床医学 | 更新时间：2021-08-23

- 不同剂量比索洛尔对充血性心力衰竭患者心率的影响
- Effect of different doses of bisoprolol on heart rate of patients with congestive heart failure
- 保健医学研究与实践 2018年15卷第3期页码：38-41
- 作者机构：
  
  重庆市第九人民医院心内科
- 作者简介：
- 基金信息：
  
  重庆市卫生计生委科研项目（20131047）
- DOI：
  中图分类号： R541.61
- 纸质出版日期：2018，
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[1]李玥,尚伟,徐中林.不同剂量比索洛尔对充血性心力衰竭患者心率的影响[J].保健医学研究与实践,2018,15(03):38-41+54.

Li Yue, Shang Wei, Xu Zhonglin. Effect of different doses of bisoprolol on heart rate of patients with congestive heart failure[J]. Health Medicine Research and Practice, 2018,15(3):38-41.
[1]李玥,尚伟,徐中林.不同剂量比索洛尔对充血性心力衰竭患者心率的影响[J].保健医学研究与实践,2018,15(03):38-41+54. DOI：

Li Yue, Shang Wei, Xu Zhonglin. Effect of different doses of bisoprolol on heart rate of patients with congestive heart failure[J]. Health Medicine Research and Practice, 2018,15(3):38-41. DOI：

摘要

目的探讨不同剂量比索洛尔对充血性心力衰竭（CHF）患者心率的影响。方法选取2015年4月-2016年6月在重庆市某医院就诊的173例CHF患者为研究对象。采用随机数字表法将患者分为对照组（n=42）、低剂量组（n=45）、中剂量组（n=42）和高剂量组（n=44）。对照组患者应用利尿剂+血管紧张素转换酶抑制剂（ACEI）+血管扩张剂+地高辛进行治疗。低、中、高剂量组患者在对照组治疗基础上加用比索洛尔进行治疗。比较治疗前及治疗6个月时

4组患者静息偶测心率、最快心率、最慢心率、平均心率、日间平均心率（8:00-20:00）、夜间平均心率（20:00-次日8:00）;比较治疗6个月时

4组患者P-R间期、QRS时限及QT间期。结果治疗后

对照组患者和低剂量组患者的静息偶测心率、最慢心率、平均心率、最快心率、日间平均心率比较

差异均无统计学意义（P>0.05）。中、高剂量组患者静息偶测心率、最慢心率、平均心率、最快心率、日间平均心率低于对照组

差异均有统计学意义（P<0.05）。中、高剂量组患者静息偶测心率、平均心率、最快心率、日间平均心率低于低剂量组

差异均有统计学意义（P<0.05）。4组患者夜间平均心率比较

差异无统计学意义（P>0.05）。中、高剂量组患者静息偶测心率、最慢心率、平均心率、最快心率、日间平均心率比较

差异均无统计学意义（P>0.05）。4组患者P-R间期、QRS时限及QT间期比较

差异无统计学意义（P>0.05）。结论应用中、高剂量比索洛尔治疗CHF的临床效果优于低剂量

且患者均未发生房室传导阻滞

证实中、高剂量比索洛尔治疗CHF是安全有效的。

Abstract

Objective To assess the effect of different doses of bisoprolol on the heart rate of patients diagnosed with congestive heart failure（CHF）.Methods A total of 173 patients with CHF treated at a Chongqing hospital between April 2015 and June 2016 were included in this study.Using a random number table

these patients were divided into the control group（n=42）

low-dose group（n=45）

medium-dose group（n=42）

and high-dose group（n=44）.Patients in the control group received routine treatment with diuretic+angiotensin-converting enzyme inhibitor（ACEI）+vasodilator+digoxin;while those in the low-

medium-

and highdose groups received routine treatment plus bisoprolol.The resting causal heart rate

maximal heart rate

minimal heart rate

mean heart rate

daytime mean heart rate（8:00-20:00）

and nighttime mean heart rate（20:00-8:00 of the following day）were measured and compared before treatment and at 6 months after treatment initiation.Besides

the P-R interval

QRS duration

and QT interval were also compared at 6 months.Results At 6 months

the resting causal heart rate

maximal heart rate

minimal heart rate

mean heart rate

and daytime mean heart rate were comparable between the control group and the low-dose group（P>0.05）.In the medium-and high-dose groups

the resting causal heart rate

maximal heart rate

minimal heart rate

mean heart rate

and daytime mean heart rate were significantly lower than those in the control group（P<0.05）

and the resting causal heart rate

maximal heart rate

mean heart rate

and daytime mean heart rate were significantly lower than those in the low-dose group（P<0.05）.The nighttime mean heart rate was similar among the 4 groups（P>0.05）.The resting causal heart rate

maximal heart rate

minimal heart rate

mean heart rate

and daytime mean heart rate were comparable between the medium-and high-dose groups（P>0.05）.No significant differences were noted in the P-R interval

QRS duration

and QT interval among the 4 groups（P>0.05）.Conclusion In patients with CHF

bisoprolol at a medium-or high-dose is more effective than low-dose without any increased risk for atrioventricular block.Based on these findings

medium-or high-dose bisoprolol is safe and effective in treating CHF.

关键词

比索洛尔充血性心力衰竭心率

Keywords

BisoprololCongestive heart failureHeart rate

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